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        Nc2Eye

           A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of diabetic retinopathy (DR)
ncRNA name mml-miR-126
ncRNA Category miRNA
Disease name diabetic retinopathy (DR)
Species Macaca mulatta
Tissues/Cell_line rhesus choroid-retinal endothelial cell line RF/6A
Methods qPCR, Western blot, scratch wound assay, transwell assay and tube formation assay, luciferase reporter assay
Expression pattern down-regulated
Functional description miR-126 overexpression inhibits the migration and sprouting of RF/6A cells induced by high glucose which might possibly be by blocking VEGFA and PIK3R2 in the VEGF/PI3K/AKT signaling pathway.
PubMed ID 28131600
Year 2017
Title MiR-126 overexpression inhibits high glucose-induced migration and tube formation of rhesus macaque choroid-retinal endothelial cells by obstructing VEGFA and PIK3R2.
Drug-related ncRNA NO

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